@nick You should read the published meta-data analysis for nicotine which says contrary to it being harmless. They do stop short of citing it as carcinogenic but do report evidence to support its role with mechanisms of causing cancer, other papers report differently and have proposed both animal and human clinical data for its role in various cancers.

Regarding nicotine’s safety profile compared with tea/coffee that would be interesting. Tea and coffees image as being healthy has been touted for a long time, not long ago Victorian doctors were saying the same about tobacco.